Results: No differences in spontaneous brain activity and global network characteristics were observed between the responder and non-responder group. In addition, in-scanner head motion was assessed. Differences between groups in spontaneous brain activity were evaluated using amplitude of low-frequency fluctuations (ALFF), while global and regional brain network characteristics were assessed using a minimum spanning tree (MST) approach. After intervention, 24 patients were classified as treatment responders and 22 as treatment resistant. Psychotherapy consisted of trauma-focused cognitive behavioral therapy (tf-CBT), eye movement desensitization and reprocessing (EMDR), or a combination thereof. Methods: Functional magnetic resonance imaging scans were acquired from 46 veterans with PTSD around the start of treatment. We studied if spontaneous brain activity, brain network characteristics and head motion during the resting state are associated with future treatment success. Investigating biological systems related to prospective treatment response is important to gain insight in mechanisms predisposing patients for successful intervention.
Introduction: Trauma-focused psychotherapy for post-traumatic stress disorder (PTSD) is effective in about half of all patients. 5Department of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.4ARQ National Psychotrauma Centre, ARQ Centre of Expertise for the Impact of Disasters and Crises, Diemen, Netherlands.3Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.2Department of Psychiatry, University Medical Centre, Utrecht, Netherlands.
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